MP: Sensitivity의 분류

Type I Hypersensitivity: IgE-mediated reactions

Immediate hypersensitivity

Type II Hypersensitivity: :Antibody-mediated Cytotoxicity

• Results when IgG or IgM bing do cell surface Ag
  – Activating Complement
  – Binding Fc receptors on Tc cells promoting Antibody-Dependent Cell-mediated Cytotoxicity (ADCC)
• Both processes result in lysis of the Ab-coated cell
• Clinical examples of Type II responses include:
   – Certain autoimmune diseases

   Grave’s Disease
Myasthenia Gravis
Autoimmune hemolytic anemia

– Hemolytic Disease of the Newborn
– Hyperacute graft rejection

Blood Transfusion reactions
Graft rejection

Type III Hypersensitivity:Immune Complex-mediated cytotoxicity

• Directed against soluble antigens caused by the deposition of
  antigen/antibody complexes in tissue and blood vessels.
• The complexes activate complement and attract ploymorphs and
  macrophages to the site.
• These cells may exocytose their granule contents and release reactive
  oxygen and nitrogen intermediates to cause local tissue damage.

Type IV Hypersensitivity:Delayed-type hypersensitivity

T-cell mediated