MP: Sensitivity의 분류

Type I Hypersensitivity: IgE-mediated reactions

Immediate hypersensitivity

Type II Hypersensitivity: :Antibody-mediated Cytotoxicity

  • Results when IgG or IgM bing do cell surface Ag
    - Activating Complement
    - Binding Fc receptors on Tc cells promoting Antibody-Dependent Cell-mediated Cytotoxicity (ADCC)
  • Both processes result in lysis of the Ab-coated cell
  • Clinical examples of Type II responses include:
     - Certain autoimmune diseases

   Grave's Disease
Myasthenia Gravis
Autoimmune hemolytic anemia

- Hemolytic Disease of the Newborn
- Hyperacute graft rejection

Blood Transfusion reactions
Graft rejection

Type III Hypersensitivity:Immune Complex-mediated cytotoxicity

  • Directed against soluble antigens caused by the deposition of
    antigen/antibody complexes in tissue and blood vessels.
  • The complexes activate complement and attract ploymorphs and
    macrophages to the site.
  • These cells may exocytose their granule contents and release reactive
    oxygen and nitrogen intermediates to cause local tissue damage.

 

Type IV Hypersensitivity:Delayed-type hypersensitivity

T-cell mediated

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